Publication
Minimal-length CAG repeats in AR define a hyperactive AR-LSD1 axis driving metabolic reprogramming in prostate cancer.
Songqi Zhang, Muqing Li, Mingyu Liu, Nolan D Patten, Maryam Labaf, Jaeweon Jeong, HyeonYeong Sun, Jared Lourie, Kai Zou, Susan Patalano, Michaela J Mulhearn, Jill A Macoska, Shuai Gao, Roberta Andreotti, Maria Pennuto, Dong Han, Steven P Balk, Changmeng Cai
- Source
- PubMed
- Retrieved
- Sep 16, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-PUBMED-20260916-000001
Abstract
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The polymorphic CAG trinucleotide repeat in the androgen receptor (AR) gene encodes a variable-length N-terminal polyglutamine (polyQ) tract that modulates AR transcriptional activity, with shorter tracts generally enhancing AR activity. While the majority of men harbor CAG repeats longer than 17,…
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Candidate 1
- cancerMalignant Prostate Neoplasmdictionary0.60
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