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Serum, cell-free, HPV-human DNA junction detection and HPV typing for predicting and monitoring cervical cancer recurrence.

Anne R Van Arsdale, Olga Meshcheryakova, Sonia Gallego, Elaine C Maggi, Bryan Harmon, Dennis Y S Kuo, Koenraad Van Doorslaer, Mark H Einstein, Brian J Haas, Cristina Montagna, Jack Lenz

eLifeSep 9, 2026PMID 42713958doi:10.7554/eLife.105741 PMC13557711Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 14, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260914-000001
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Almost all cervical cancers are caused by human papillomaviruses (HPVs). In most cases, HPV DNA is integrated into the human genome. We found that tumor-specific, HPV-human DNA junctions are detectable in serum cell-free DNA of a fraction of cervical cancer patients at the time of initial treatment…

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