Publication
The DNA/RNA Helicase SETX Maintains R-Loop Homeostasis to Promote Chemoresistance in Ovarian Cancer.
Zi-Wei Hu, Tu-Nan Xu, Zi-Ying Wang, Xin Zheng, Duan-Yong Feng, Xiao-Min Wang, Er-Suo Jin, Ming Ren, Xiao-Min Yang, Xian-Chao Zhang, Xuan Che, Wei-Wei Pan, Zha-Jun Zhan, Shu-Qun Cheng
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- PubMed
- Retrieved
- Sep 15, 2026
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- normalized (units and labels harmonized; values unchanged)
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- ING-PUBMED-20260915-000001
Abstract
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Ovarian cancer is a lethal malignancy that frequently develops resistance to platinum-based chemotherapies. Elucidating the genes that regulate DNA damage repair could lead to more effective treatments for ovarian cancer. Senataxin (SETX), an RNA-DNA helicase, maintains R-loop homeostasis to ensure…
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- cancerMalignant Ovarian Neoplasmdictionary0.60
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