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Frontline therapies for adult patients with newly diagnosed Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia: a systematic literature review.

Maria Virginia Meza, Sarah Hodgkinson, Christian Stefan Eichinger, Faraz Zaman, Diana Boyko

Hematology (Amsterdam, Netherlands)Dec 31, 2026PMID 42711755doi:10.1080/16078454.2026.2720973 Journal ArticleSystematic ReviewpubmedProvenance
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PubMed
Retrieved
Sep 29, 2026
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normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260929-000001
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OBJECTIVES: Philadelphia (Ph) chromosome-negative B-cell acute lymphoblastic leukemia (B-ALL) is the most common ALL in adults. Overall survival (OS) with frontline chemotherapy remains poor. Blinatumomab is currently the only targeted agent approved for frontline treatment. METHODS: We…

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