Publication
MCAT-mediated mitochondrial fatty acid metabolism regulates Lauren subtype divergence and suppresses gastric cancer progression through ROS/P53-dependent mitophagy and ferroptosis.
Yufei Wang, Meng Zhu, Xin Yin, Tianyi Fang, Lei Zhang, Yujuan Jiao, Hongxin Wang, Zipu Dong, Tengteng Liu, Yingwei Xue
Cell death and differentiationSep 8, 2026PMID 42711380doi:10.1038/s41418-026-01867-7 Journal ArticlepubmedProvenance
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- Sep 14, 2026
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- ING-PUBMED-20260914-000001
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Gastric cancer (GC) displays marked heterogeneity under the Lauren classification, yet the metabolic determinants of subtype divergence remain unclear. Here, we identify Malonyl-CoA:ACP transacylase (MCAT), a Lauren subtype-associated gene encoding a key mitochondrial fatty acid synthesis (mtFAS)…
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- cancerMalignant Gastric Neoplasmdictionary0.60
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