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Metabolic predictors of response to immunotherapy in locally advanced or metastatic esophageal cancer: unveiling the obesity paradox.

Jiaqi Tan, Haoyu Zhang, Zhaoyu Pan, Yuhan Chen, Xiaoqiao Cui, Xueying Wang, Gangcai Zhu

Scientific reportsSep 9, 2026PMID 42711346doi:10.1038/s41598-026-49080-3 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 19, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260919-000001
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PD-1 inhibitor-based immunotherapy is increasingly used for locally advanced or metastatic esophageal cancer, yet the impact of metabolic factors-including the emerging "obesity paradox", wherein high-body mass index (BMI) patients demonstrate a lower risk of all-cause cancer mortality and superior…

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