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Cancer-associated fibroblast-enriched TAGLN orchestrates HGF/c-MET-dependent transcriptional reprogramming in gastric cancer.

Qiang Li, Jianing Yang, Luhong Cao, Qiushuang Wang, Junfeng Yan, Guiyang Ye, Linxue Huang, Yi Wang, Qiang Tong

Cancer lettersSep 8, 2026PMID 42710828doi:10.1016/j.canlet.2026.218832 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 14, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260914-000001
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Recurrence and peritoneal metastasis remain major challenges in gastric cancer (GC), highlighting the need to identify actionable stromal-tumor signaling circuits within the tumor microenvironment (TME). Integrated transcriptomic analyses and clinical validation identified TAGLN as a…

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