Publication
PARP16 is a Druggable Regulator of Ribosome MARylation and Protein Homeostasis in Ovarian Cancer Cells.
Sridevi Challa, Morgan Dasovich, Jonathan C Abshier, Komal Pekhale, Lu Yang, Cristel V Camacho, W Lee Kraus
The Journal of biological chemistrySep 8, 2026PMID 42710679doi:10.1016/j.jbc.2026.113540 Journal ArticlepubmedProvenance
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- Sep 14, 2026
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- ING-PUBMED-20260914-000001
Abstract
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Cytosolic NAD+ synthesis supports ovarian cancer growth by enabling PARP16-dependent mono(ADP-ribosyl)ation (MARylation) of ribosomal proteins, thereby fine-tuning translation and maintaining protein homeostasis. While genetic depletion of PARP16 disrupts ribosome MARylation and impairs tumor cell…
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- cancerMalignant Ovarian Neoplasmdictionary0.60
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