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Graph neural network-based risk stratification of prostate cancer using gene expression and SHAP interpretability.

Saeed Pirmoradi, Sevil Vaghefi Moghaddam, Mohammadreza Ardalan, Mir Mohsen Sharifi Bonab, Mohammad Teshnehlab, Sepideh Zununi Vahed

PloS oneJan 1, 2026PMID 42709904doi:10.1371/journal.pone.0356727 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 9, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260909-000004
Published

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Accurate risk stratification is essential for guiding treatment decisions and preventing over treatment of prostate cancer, which remains one of the most prevalent cancers among adult men. While the Gleason score, obtained from prostate biopsies, is routinely used to assess tumor aggressiveness,…

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