Publication
EPHA2 and WNT reciprocally regulate MAPK-dependent gene expression in a pancreatic cancer model.
Shawn R Wadia, Changyuan Hu, Siddhi Patnaik, Shreya Sridharan, Roger J Daly, David M Virshup, Babita Madan
JCI insightSep 8, 2026PMID 42709684doi:10.1172/jci.insight.202630 Journal ArticlepubmedProvenance
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- PubMed
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- Sep 11, 2026
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- ING-PUBMED-20260911-000001
Abstract
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Wnt signaling drives tumorigenesis in multiple cancers, in part through complex interactions with other oncogenic pathways including the MAPK cascade. In Wnt-addicted cancers, pharmacologic and genetic inhibition of Wnt signaling activates multiple receptor tyrosine kinases (RTKs), increases ERK…
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- cancerMalignant Pancreatic Neoplasmdictionary0.60
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