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Thioredoxin reductase-1 facilitates cellular plasticity and stemness mediated by TGF-β1 in non-small cell lung cancer.

Yaw-Dong Lang, Shin-Yuan Gu, Jou-Ho Shih, Chun-Jung Lin, Hua-Hsin Chiang, Tsai-Yu Lin, Yu-Ching Lee, Keng-Chang Tsai, Jui-Tin Chang, Cheng-Ying Chu, Yuh-Shan Jou, Teh-Ying Chou

Cancer biology & therapyDec 31, 2026PMID 42709540doi:10.1080/15384047.2026.2724630 PMC13556941Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 29, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260929-000001
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BACKGROUND: Cellular plasticity and epithelial-mesenchymal transition (EMT) promote the initiation and progression of non-small cell lung cancer (NSCLC). Thioredoxin reductase 1 (TXNRD1), a key redox enzyme, has been linked to malignancy, but its mechanism in NSCLC remains unclear. We examined…

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