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Computational and experimental evaluation of curcumin as a DNMT3B-targeting epigenetic modulator in pancreatic cancer.

Ali Afgar, Saeed Zanganeh, Roohollah Mirzaee Khalilabadi, Tahereh Haghpanah, Mostafa Amopour Bahnamiry, Hoda Ebrahimi, Mohamad Javad Mirzaei-Parsa, Batoul Kavyani

In silico pharmacologyJan 1, 2026PMID 42707300doi:10.1007/s40203-026-00717-1 PMC13547192Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 11, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260911-000001
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Pancreatic cancer remains a therapeutic challenge due to its aggressive nature and resistance to conventional therapies. This study investigates the epigenetic effects of curcumin on the miR-29b/DNMT3B/MUC1 axis in pancreatic cancer cells (MIA PaCa-2) through an integrated bioinformatics and…

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