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Dual‑Channel Hypoxia Detection Using PET-Based Water-Soluble Cyanine Probes to Suppress False Negatives in Image‑Guided Pancreatic Cancer Resection.

Huiling Huang, Shihao Jiang, Zhipengjun Zhang, Ye Chen, Zhihua He, Haifeng Ge, Guojiang Mao, Lei Zhou, Hongwen Liu

Advanced healthcare materialsSep 7, 2026PMID 42706780doi:10.1002/adhm.71693 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 11, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260911-000001
Published

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Fluorescence‑guided surgery using activatable probes is promising, but single‑channel probes often give false negatives-especially in pancreatic cancer due to tumor heterogeneity and limited imaging depth. Here, we built a universal charge-switching gated PET platform based on cyanine dyes bearing…

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