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Transcriptomic analysis of a phase 1 trial for intraperitoneal monocytes plus IFNs in ovarian cancer reveals support and recruitment of cell-mediated immunity.

Franklin Ning, Emily San Andres-Montalvan, Thomas J Meyer, Sabina Kaczanowska, Rosie Kaplan, Christina M Annunziata

Journal for immunotherapy of cancerSep 7, 2026PMID 42705863doi:10.1136/jitc-2026-014938 PMC13561009Journal ArticleClinical Trial, Phase IpubmedProvenance
Source
PubMed
Retrieved
Sep 14, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260914-000001
Published

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BACKGROUND: Ovarian cancer is the most lethal gynecological malignancy and lacks therapeutic options in the recurrent setting. We previously determined the safety and initial clinical activity of intraperitoneal autologous monocytes with interferon gamma and interferon alpha (AMIGA) in women with…

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