Publication
A microbial chromatin remodeler drives gastric cancer progression and immune evasion by reprogramming the host epigenome.
Xiaoshan Xie, Yue Wei, Jiaying Zheng, Zhikai Zheng, Xijie Chen, Jiarui Wang, Ning Ma, Xiaoling Huang, Peng Zhang, Boyu Zhang, Hanyong Cai, Li Ma, Lishi Xiao, Qingxin Liu, Wenyu Wang, Sachiyo Nomura, Shi Chen, Xiangqi Meng, Mong-Hong Lee
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- PubMed
- Retrieved
- Sep 12, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-PUBMED-20260912-000001
Abstract
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First-line treatment for gastric cancer (GC) includes PD-1 blockade with chemotherapy, but resistance challenges treatment success. We identify Streptococcus anginosus (SA) as a tumor-resident oncobacterium driving GC progression and immune evasion. SA is enriched in GC patient tumors and drives…
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Candidate 1
- cancerMalignant Gastric Neoplasmdictionary0.60
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