Publication
Metabolic Activation-Dependent Anti-Liver Cancer Activity and Organ-Specific Toxicity of Retrorsine From Fanhuncao (Jacobaea cannabifolia and J. litvinovii).
Zhijie He, Zhongyu Tan, Lunrong Zhang, Yue Yin, Yedeli Yerjiang, Bo Bi, Jingshan Bao
Archiv der PharmazieSep 1, 2026PMID 42704289doi:10.1002/ardp.70326 PMC13548937Journal ArticlepubmedProvenance
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- PubMed
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- Sep 14, 2026
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- normalized (units and labels harmonized; values unchanged)
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- ING-PUBMED-20260914-000001
Abstract
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Fanhuncao (Jacobaea cannabifolia and J. litvinovii) is a traditional Chinese herb with reported antitumor potential. Retrorsine, a pyrrolizidine alkaloid from Fanhuncao, requires CYP3A4‑mediated metabolic activation, but its dual outcomes (anti‑liver cancer efficacy vs. organ‑specific toxicity)…
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- cancerMalignant Liver Neoplasmdictionary0.60
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