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Profiling neoadjuvant therapy response in rectal cancer using meta-analysis of publicly available transcriptomic RNA-seq datasets.

Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic-Rundic, Radmila Jankovic, Sergi Castellvi-Bel, Remond J A Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic

Molecular oncologySep 7, 2026PMID 42703166doi:10.1002/1878-0261.70324 PMC13548026Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 18, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260918-000001
Published

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Neoadjuvant chemoradiotherapy followed by total mesorectal excision is standard for locally advanced rectal cancer, but response varies and current markers are insufficient. This study integrates public bulk RNA-seq data to identify predictive features of response. TRIM54 and PABPC4 were…

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