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Progesterone Is Associated With Increased Vasohibin-2 Expression, Tubulin Detyrosination, and Paclitaxel Sensitivity in PR-Negative Ovarian Cancer Cells.

Takahiro Koyanagi, Yasushi Saga, Yoshifumi Takahashi, Kohei Tamura, Eri Suizu, Kazuki Yamamoto, Akiyo Taneichi, Yuji Takei, Hiroaki Mizukami, Hiroyuki Fujiwara

Cancer reports (Hoboken, N.J.)Sep 1, 2026PMID 42702875doi:10.1002/cnr2.70681 PMC13547742Journal ArticleResearch Support, Non-U.S. Gov'tpubmedProvenance
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PubMed
Retrieved
Sep 10, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260910-000001
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BACKGROUND: Progesterone induces rapid cellular responses in progesterone receptor (PR)-negative ovarian cancer cells that are consistent with non-genomic progesterone signaling. Vasohibin-2 (VASH2), originally identified as a pro-angiogenic factor, has recently been recognized as a tubulin…

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