Publication
Mechanism of cancer-associated fibroblasts-derived exosomes-shuttled snail regulating the SOCS6/HIF-1α axis to promote pancreatic cancer stemness and gemcitabine resistance.
Zhen Luo, Yuqin Hu, Jian Li, Dayong Xu, Jin Xu, Hao Li, Fang Zou
Cellular signallingSep 5, 2026PMID 42700784doi:10.1016/j.cellsig.2026.112876 Journal ArticlepubmedProvenance
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- PubMed
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- Sep 10, 2026
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- normalized (units and labels harmonized; values unchanged)
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- ING-PUBMED-20260910-000001
Abstract
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OBJECTIVE: Cancer-associated fibroblasts (CAFs) contribute to pancreatic cancer (PC) progression and therapeutic resistance. This study investigated whether CAF-derived exosomes (CAF-exo)-promote PC cell stemness and gemcitabine (GEM) resistance by delivering Snail and regulating the suppressor of…
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- cancerMalignant Pancreatic Neoplasmdictionary0.60
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