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Decluttering chemotherapy agents for HER2+early breast cancer: Do we still need carboplatin?

Fabio Conforti, Jacopo Canzian, Benedetta Tinterri, Laura Pala, Marzia Bendoni, Marzia Locatelli, Tommaso De Pas, Aldo Caltavituro, James C Dickerson, Carmen Criscitiello, Francesco Schettini, Aleix Prat, Javier Cortes, Giuseppe Viale, Martine Piccart, Richard Gelber

European journal of cancer (Oxford, England : 1990)Oct 16, 2026PMID 42700699doi:10.1016/j.ejca.2026.117015 Journal ArticleReviewpubmedProvenance
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PubMed
Retrieved
Oct 2, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20261002-000001
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Over the past two decades, targeted anti-HER2 therapies have transformed management of HER2-positive early breast cancer (HER2 + eBC), enabling chemotherapy de-escalation without compromising efficacy. This review assesses the rationale for incorporating carboplatin into (neo)adjuvant regimens and…

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