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Oncologic Outcomes in a Contemporary "PROTEUS-like" Cohort of High-risk Prostate Cancer Treated with Radical Prostatectomy Without Neoadjuvant Hormonal Therapy.

Can Aydogdu, Benso John, Clara Seizer, Frederik Kolligs, Iason Papadopoulos, Alexander Buchner, Elena K Berg, Jozefina Casuscelli, Julie Steinestel, Roman Mayr, Matthias Heck, Christian G Stief, Thilo Westhofen

European urology open scienceOct 1, 2026PMID 42699359doi:10.1016/j.euros.2026.08.001 PMC13543131Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 19, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260919-000001
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BACKGROUND AND OBJECTIVE: High-risk prostate cancer (PCa) carries substantial risks of recurrence, metastasis, and mortality. Neoadjuvant therapy before radical prostatectomy (RP) remains investigational. The PROTEUS (NCT03767244) trial evaluates perioperative apalutamide + androgen deprivation…

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Registered trialsNCT03767244

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