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Association between smoking, tumor genetics, and outcomes in men with metastatic prostate cancer.

Christopher Choi, Matthew Labriola, Nicholas Henderson, Alec Chu, Clara Hwang, Pedro C Barata, Frank Cameron Cackowski, Amanda Broderick, Rana R McKay, Mehmet Asim Bilen, Deepak Kilari, Laura S Graham, Abhishek Tripathi, Rohan Garje, Vadim S Koshkin, Tanya B Dorff, Michael Thomas Schweizer, Zachery R Reichert, Alexandra O Sokolova, Catherine H Marshall, Andrew J Armstrong

Prostate cancer and prostatic diseasesSep 5, 2026PMID 42697914doi:10.1038/s41391-026-01150-3 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260908-000003
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PURPOSE: Smoking has been associated with increased metastatic prostate cancer mortality, but the mechanisms behind this are largely unknown. We hypothesized that smoking increases the risk of genetic alterations associated with aggressive disease and/or the transformation to neuroendocrine…

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