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Chemotherapy Reawakens Dormant Disseminated Pancreatic Cancer Cells in the Liver by Promoting Senescent Hepatocyte-Induced Neutrophil Extracellular Traps.

Shangheng Shi, Jingrui Yan, Yu Zhang, Yaqi Zhang, Guohua Mao, Tinghai Hu, Jingbo Xu, Fanyue Shao, Jiaqi Mao, Liangliang Wu, Rui Liu, Wenna Jiang, Chuntao Gao, Jihui Hao, Tianxing Zhou

Cancer researchSep 4, 2026PMID 42696464doi:10.1158/0008-5472.CAN-26-0151 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 10, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260910-000001
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Chemotherapy remains a cornerstone treatment for pancreatic ductal adenocarcinoma (PDAC), yet it paradoxically promotes metastatic recurrence. Elucidation of the underlying mechanisms mediating chemotherapy-induced metastasis could help identify improved combination treatment strategies. Here, we…

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