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Time-dependent effects of BCG plus immune checkpoint inhibitors in BCG-naive high-risk non-muscle-invasive bladder cancer: a reconstructed patient-level analysis.

Shugo Yajima, Soichiro Yoshida, Wei Chen, Hiroshi Fukushima, Hajime Tanaka, Hiroyuki Sato, Akihiro Hirakawa, Hitoshi Masuda, Yasuhisa Fujii

International urology and nephrologySep 4, 2026PMID 42696081doi:10.1007/s11255-026-05373-0 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 15, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260915-000001
Published

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PURPOSE: Three phase 3 trials (CREST, POTOMAC, ALBAN) adding an immune checkpoint inhibitor (ICI) to Bacillus Calmette-Guérin (BCG) in BCG-naive high-risk non-muscle-invasive bladder cancer (NMIBC) reported different results. We used reconstructed individual patient-level data (rIPD) to examine the…

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