Publication
SIX1 drives acute myeloid leukemia progression by reprogramming glycolytic metabolism and impairing CD8⁺ T-cell effector function.
Hui Hou, Ruijun Li, Lei Zhao, Yan Ma, Jingjing Zhao, Junli Li, Jianping Liu, Yumin Wang, Luqiang Zhang
Immunologic researchSep 4, 2026PMID 42693356doi:10.1007/s12026-026-09803-0 PMC13541876Journal ArticlepubmedProvenance
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- Sep 17, 2026
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- ING-PUBMED-20260917-000001
Abstract
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This study aimed to investigate the role of the homeobox gene SIX1 (sine oculis homeobox homolog 1) in acute myeloid leukemia (AML) progression and to explore its underlying metabolic and immunological mechanisms. SIX1 expression was examined in human bone marrow stromal cells (HS-5) and AML cell…
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- cancerLeukemiadictionary0.60
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