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Zirconium metal-organic framework-based composite drug delivery system for precise drug release and synergistic modulation of the tumor microenvironment in liver cancer therapy.

Yujia Han, Haixiang Zeng, Jing Xu, Hongyan Hao, Hongxia Li, Xiaohui Niu, Yan Li, Xiaoyu Liu, Deyi Zhang, Li Chen, Dongqiang Zhang, Kunjie Wang

Acta biomaterialiaSep 3, 2026PMID 42692231doi:10.1016/j.actbio.2026.09.006 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 15, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260915-000001
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Zirconium-based metal-organic framework (MOF-808) materials were selected as drug delivery carriers, with 5-fluorouracil (5-Flu) as the model drug. MOF-808@5-Flu drug-loaded carriers were designed and prepared at different ratios. The drug release behavior of the MOF-808@5-Flu nanocomposite was…

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