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CLDN18 as a novel junctional biomarker enhancing multi-gene classification of pancreatic cancer.

Jessie Santoro, Lisa Agnello, Andrea Colacino, Ilaria Leone, Joel Verísimo-García, Eleonora Viscusi, Stefano Laudati, Giuseppe Iannaci, Antonio D'Antonio, África González-Fernández, Valentina De Falco, Immacolata Maietta

Translational oncologySep 3, 2026PMID 42691511doi:10.1016/j.tranon.2026.102993 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 9, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260909-000004
Published

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Pancreatic adenocarcinoma (PAAD) remains one of the most lethal cancers, largely due to the lack of reliable diagnostic biomarkers. Through integrative transcriptomic and proteomic analyses, we evaluated a four-gene signature comprising CLDN18, CEACAM5, FUT3, and FUT6, capable of distinguishing…

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