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A phase II randomized study of proton therapy vs intensity-modulated radiation therapy in patients with unilateral head and neck cancer.

Edward Christopher Dee, Noah S Kalman, Daniel J Ma, Scott C Lester, Zhigang Zhang, Daphna Gelblum, Yao Yu, Linda Chen, Sean M McBride, Nadeem Riaz, Boris A Mueller, Achraf Shamseddine, Kaveh Zakeri, Jung Julie Kang, Chiaojung Jillian Tsai, Yingzhi Wu, Dennis Mah, Kevin Sine, Andy Shim, Haibo Lin, Alan Ho, Richard J Wong, Paul B Romesser, Christopher A Barker, Nancy Y Lee

Journal of the National Cancer InstituteSep 3, 2026PMID 42690689doi:10.1093/jnci/djag257 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 30, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
Published

Abstract

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Proton beam radiotherapy (PBRT) offers dosimetric advantages over intensity-modulated radiation therapy (IMRT), but prospective randomized data in the postoperative unilateral head and neck cancer setting remain limited. We conducted a multicenter, randomized phase II trial comparing PBRT and IMRT…

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Registered trialsNCT02923570

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