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H3K18 Lactylation Promotes Cell Proliferation in T-Cell Acute Lymphoblastic Leukemia.

Lingling Feng, Xia Jin, Juan Zhang, Zong Zhai, Xiaohua Zhang, Yi Wang

Journal of cellular biochemistrySep 1, 2026PMID 42687432doi:10.1002/jcb.70120 PMC13539116Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 9, 2026
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normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260909-000004
Published

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The Warburg effect-induced lactate production in T-cell acute lymphoblastic leukemia (T-ALL) cell proliferation is well established, however, the role of lactate-mediated protein lactylation in this process remains poorly understood. In this study, we demonstrated that inhibiting lactate levels…

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