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ASC-J9 attenuates the metastatic potential of oral cancer cells by downregulating the STAT3/ITGB8 signaling pathway.

Pei-Ni Chen, Chiao-Wen Lin, Chih-Ting Lai, Shun-Fa Yang, Yu-Chao Chang

European journal of pharmacologyOct 15, 2026PMID 42685816doi:10.1016/j.ejphar.2026.179306 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 30, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
Published

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Dimethylcurcumin (ASC-J9), a derivative of curcumin, has been reported to possess anticancer activity. However, its potential impact on oral squamous cell carcinoma (OSCC) has not been fully characterized. In this study, we aimed to determine whether ASC-J9 inhibits OSCC metastasis and to elucidate…

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