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Xanthomicrol shifts the ERα/ERβ balance and promotes a less aggressive phenotype in SKOV‑3 ovarian cancer cells.

Isis Santos, Gabriel Gutiérrez-Ospina, Adelina Jiménez-Arellanes, Norma Oviedo, Gerardo Perera-Marín, Eunice López-Muñoz, Arturo Aguilar-Rojas, Aleida Olivares

Natural product researchSep 2, 2026PMID 42685347doi:10.1080/14786419.2026.2724379 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 10, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260910-000001
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Conventional therapies for epithelial ovarian cancer (EOC) often fail to prevent metastasis and recurrence. A critical determinant of EOC behaviour is the ERα/ERβ ratio, where ERα promotes tumorigenesis and ERβ exerts tumour-suppressive effects. This study investigated the effects of xanthomicrol,…

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