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An Exosomal Signature for Preoperative Detection of Occult Liver Metastasis in Pancreatic Cancer.

Takayuki Noma, Jingyang Yin, Junfeng Zhang, Caiming Xu, Mitsuro Kanda, Song Cheol Kim, Yuji Morine, Mitsuo Shimada, Vincent Chung, Ali H Zaidi, Daniel Von Hoff, Huaizhi Wang, Ajay Goel

JAMA surgerySep 2, 2026PMID 42684725doi:10.1001/jamasurg.2026.3840 PMC13539454Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260908-000003
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IMPORTANCE: Early liver metastasis (early-LiM) after pancreatectomy represents an aggressive biological phenotype of pancreatic ductal adenocarcinoma (PDAC) and is associated with markedly poor survival. Reliable preoperative biomarkers to identify occult hepatic micrometastasis remain…

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