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A phase II multi-institutional single arm trial evaluating TG4010 vaccine plus nivolumab in non-small cell lung cancer.

Charles X Wang, Guillaume Luxardi, Hidetoshi Mori, Emanual M Maverakis, Alexander A Merleev, Alina I Marusina, Alexander D Borowsky, Mamta Parikh, Jonathan W Riess, Ala Moshiri, Lyudmila Bazhenova, Matthew Gubens, Marianna Koczywas, Joseph D Butner, Jonathan Huang, Soo Kyoung Kim, Logan V Vick, Yaohui Sun, Robert J Canter, William J Murphy, Megan E Daly, Karen Kelly, Arta M Monjazeb

OncoimmunologyDec 31, 2026PMID 42684015doi:10.1080/2162402X.2026.2695491 PMC13540112Journal ArticleMulticenter StudyClinical Trial, Phase IIpubmedProvenance
Source
PubMed
Retrieved
Sep 29, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260929-000001
Published

Abstract

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Immune checkpoint inhibitors (ICIs) have transformed non-small cell lung cancer (NSCLC) therapy, but only 25% of patients have durable responses. TG4010, a mucin 1 (MUC1) vaccine, has demonstrated activity in NSCLC. We conducted a multi-institutional study to determine the safety and activity of…

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Registered trialsNCT02823990

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