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Sanguinarine chloride inducing ferroptosis and downregulating GPX4 expression in liver cancer: An integrated in silico, in vitro and in vivo study.

Wen Ouyang, Jianxin Gao, Jing Liu, Lulu Qin, Bang Liu, Ying He, Dai Zhou

Experimental and therapeutic medicineOct 1, 2026PMID 42683259doi:10.3892/etm.2026.13266 PMC13531337Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 10, 2026
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normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260910-000001
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Ferroptosis, an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, has been increasingly implicated in the development and progression of liver cancer. Despite sanguinarine chloride (SC) exhibiting antitumor activity in a number of cancer models, whether it…

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