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Small Extracellular Vesicle and Total Lipid Profiles Provide a Diagnostic Advantage Over CA-125 Across Ovarian Cancer Subtypes.

Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz-Romero, Lewis Perrin, Rohan Lourie, Vaibhavi Joshi, Amy E McCart Reed, Kaltin Ferguson, Aase Handberg, Andreas Möller, Carlos Salomon

Journal of extracellular vesiclesSep 1, 2026PMID 42680694doi:10.1002/jev2.70348 PMC13533800Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260908-000003
Published

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Ovarian cancer remains the most lethal gynaecological malignancy, largely due to late-stage diagnosis and the limited sensitivity of CA-125 for borderline and low-grade tumours. Dysregulated lipid metabolism may provide complementary diagnostic information. This study aimed to develop lipid-based…

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