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Thonzonium bromide suppresses malignant phenotypes of pleural mesothelioma cells in association with reduced KAP1 Ser473 phosphorylation.

Dan Song, Jintao He, Qianwen Du, Shaoyang Huang, Wenbing Huang, Zhengliang Li, Zifeng Ruan, Xingguo Liu, Jing Zhang, Wei Xiong

Tissue & cellAug 22, 2026PMID 42679618doi:10.1016/j.tice.2026.103889 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260908-000002
Published

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OBJECTIVE: Pleural mesothelioma (PM) is an aggressive thoracic malignancy with limited therapeutic options. This study investigated the biological role of KAP1 in PM and explored the relationship between thonzonium bromide (TB), KAP1 regulation, and malignant phenotypes of PM cells. METHODS: KAP1…

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