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Multi-omics integration in malignant pleural mesothelioma: from molecular evolution and immune ecosystems to precision therapy.

Hongmei Li, Kunzhong Zhou, Ruiting Xu, Weifang Wang, Tingting Song, Yonghong Zhou, Jing Ren, Zhiyong Wang, Yiteng Liang, Yilin Chen, Saurav Poudel, Junxuan Yu, Rui Lin, Ke Yin, Shengjie Yang, Li Zhuang

Frontiers in oncologyJan 1, 2026PMID 42676823doi:10.3389/fonc.2026.1883870 PMC13527837Journal ArticleReviewpubmedProvenance
Source
PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260908-000002
Published

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Malignant pleural mesothelioma (MPM) exhibits substantial molecular and cell-state heterogeneity, together with marked spatial variation in its immune and stromal microenvironment. Histological classification and individual biomarkers alone cannot adequately explain its evolution or heterogeneous…

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