Publication
Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Aug 30, 2026PMID 42669594doi:10.1002/advs.77458 PMC13526533Journal ArticlepubmedProvenance
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- Sep 13, 2026
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- ING-PUBMED-20260913-000001
Abstract
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Toosendanin (TSN) is a highly potent natural anticancer compound derived from the fruit of Fructus Meliae Toosendan. In this study, TSN inhibited melanoma cell proliferation and cell-cycle progression, induced apoptosis, and suppressed metastasis in both in vitro and in vivo models. TSN is a potent…
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- cancerCutaneous Melanomadictionary0.60
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