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An immune-activated co-culture model of patient-derived gastric cancer organoids and peripheral blood mononuclear cells for personalized chemotherapy screening.

Yefan Yu, Wei Chen, Ningfei Jia, Chen Wang, Juan Lan, Shuying Yan, Tiefeng Cao, Yan Huang, Rui L Reis, Joaquim M Oliveira, Leping Yan, Lin Xiao

Acta biomaterialiaOct 1, 2026PMID 42669342doi:10.1016/j.actbio.2026.08.053 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Oct 2, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20261002-000001
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Selecting effective chemotherapy after immunotherapy remains a major clinical challenge in advanced gastric cancer because patient responses are highly heterogeneous. A major obstacle is the lack of personalized preclinical models that faithfully recapitulate the immune-activated tumor…

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