Publication
Repurposing butoconazole as a GRP78 substrate-binding domain (SBD) inhibitor to induce endoplasmic reticulum stress-mediated apoptosis in triple-negative breast cancer.
Yaowen Song, Ziyue Yuan, Zhijia Li, Yunli Huang, Yingying Lu, Qianqian Yang, Yan Wang, Lan Zhang, Wei Ma
Bioorganic chemistryOct 5, 2026PMID 42669273doi:10.1016/j.bioorg.2026.110447 Journal ArticlepubmedProvenance
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- Sep 26, 2026
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- ING-PUBMED-20260926-000001
Abstract
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Triple-negative breast cancer (TNBC) is aggressive with limited therapies and poor prognosis. Butoconazole, a clinical topical imidazole antifungal for vulvovaginal candidiasis, has not previously been investigated for TNBC treatment. Here, we repurposed butoconazole as a novel allosteric inhibitor…
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- cancerMalignant Breast Neoplasmdictionary0.60
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