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Harnessing necroptosis via RIPK1 degradation to potentiate radio-immunotherapy in cervical cancer.

Tong Wu, Bin Lv, Han Wang, Guangping He, Yuandong Fu, Xiuru Ji, Yulian Zeng, Dalong Ni, Junjun Qiu, Keqin Hua

Bioactive materialsJan 1, 2027PMID 42668673doi:10.1016/j.bioactmat.2026.08.020 PMC13524860Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 19, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260919-000001
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Immune checkpoint inhibitors (ICIs) are first-line therapy for cervical cancer (CC), yet their efficacy is limited to a subset of patients owing to low tumor immunogenicity. Single-cell RNA sequencing revealed that CC patients exhibiting robust immune responses following radiotherapy (RT) showed…

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