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Synthesis and biological evaluation of optically active Z250-1659 as a synthetic lethal agent against BAP1-deficient mesothelioma cells.

Tomohiro Tsutsumi, Airi Wada, Hikari Yamamoto, Momoko Sato, Sana Tsukioka, Mengshi Qiu, Koya Suzuki, Ayato Sato, Yuko Murakami-Tonami, Ichiro Hayakawa

Bioorganic & medicinal chemistryAug 26, 2026PMID 42660065doi:10.1016/j.bmc.2026.118782 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 8, 2026
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normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260908-000002
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Synthetic lethality has emerged as an attractive therapeutic strategy for cancers harboring tumor suppressor gene alterations, as exemplified by the clinical success of PARP inhibitors in BRCA1/2-deficient cancers. We identified (±)-Z250-1659 as a synthetic lethal compound against BAP1-deficient…

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