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Imaging-Detected Extranodal Extension in p16-Positive Oropharyngeal Cancer: Secondary Analysis of RTOG 1016.

Christopher W Fleming, Chandana A Reddy, Sarah Stock, Jonathan Lee, Maura Gillison, Jimmy J Caudell, Jessica L Geiger, Dukagjin M Blakaj, Greg A Krempl, A Dimitrios Colevas, Christopher U Jones, Nabil F Saba, Jack Phan, Thomas J Galloway, Samantha Seaward, Sharon Spencer, Pedro Torres-Saavedra, Sue S Yom, Quynh-Thu Le, Shlomo A Koyfman

JAMA otolaryngology-- head & neck surgeryAug 27, 2026PMID 42658511doi:10.1001/jamaoto.2026.0932 PMC13522994Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 26, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260926-000001
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IMPORTANCE: Imaging-detected extranodal extension (iENE) has been included in the American Joint Committee on Cancer (AJCC) and Union for International Cancer Control (UICC) protocol tumor-node-metastasis 9th edition staging system (TNM9) for human papillomavirus (HPV)-mediated (p16-positive)…

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Registered trialsNCT01302834

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