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Intraoperative esketamine for postoperative analgesia and depression in pancreatic cancer surgery: protocol for a multicenter randomized controlled trial.

Ying-Zi Chong, Yu-E Sun, Xiaqing Ma, Han-Xue Zhao, Bing-Yuan Zhang, Qi-Hong Zhao, Meng-Jiao Yang, Fu-Hai Ji, Lin Jiang, Ke Peng

Annals of medicineDec 1, 2026PMID 42657795doi:10.1080/07853890.2026.2722438 PMC13523955Journal ArticleClinical Trial ProtocolResearch Support, Non-U.S. Gov'tpubmedProvenance
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PubMed
Retrieved
Sep 26, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260926-000001
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INTRODUCTION: Patients undergoing pancreatic cancer surgery frequently experience severe postoperative pain and a high prevalence of depression. Esketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, offers rapid-onset analgesic and antidepressant properties, yet its efficacy in this…

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