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Network pharmacology-guided identification of Rabdosia rubescent as a suppressor of laryngeal cancer via MMP9-mediated extracellular matrix remodeling: integrated in silico and experimental validation.

Xuefeng Wang, Guanying Ren, Yonggang Zhang, Yu Peng, Ruiyao Wang, Yang Li, Jingyu Wang, Sicong Jia, Jingyun Li, Lei Song, Yan Shi

Frontiers in pharmacologyJan 1, 2026PMID 42656310doi:10.3389/fphar.2026.1855812 PMC13506694Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 11, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260911-000001
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BACKGROUND: Laryngeal cancer, particularly laryngeal squamous cell carcinoma (LSCC), poses a significant threat to global health, especially within Asian populations. While Rabdosia Rubescens is known for its antitumor properties, the specific bioactive compounds and mechanisms underlying its…

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