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Discovery of quinazoline-based dual RET/Aurora B inhibitors for non-small cell lung cancer.

Maha Hanafi, Baha'a Jabali, Daniel Armstrong, Eva R Palmer, Gavin Hargrove, Baku Acharya, Halle Morgan, Emily Kanwischer, Ashton Hale, Paige Spicer, Brendan Frett

Bioorganic chemistryOct 5, 2026PMID 42648234doi:10.1016/j.bioorg.2026.110399 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 19, 2026
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normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260919-000001
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RET and Aurora B (AurB) kinases play critical roles in tumor growth and survival in non-small cell lung cancer (NSCLC), yet monotherapy approaches are frequently undermined by acquired resistance and tumor heterogeneity. Here, we report the discovery of dual RET/AurB inhibitors with potent activity…

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