Publication
Autocrine Control of CD276 by SPARC in Liver Cancer and Its Contribution to Immune Escape and Resistance to Immunotherapy: Elucidating How SPARC Shapes the Tumor Microenvironment and Undermines the Response to Immune Checkpoint Inhibition.
Mengying Tang, Jing Liu
Journal of biochemical and molecular toxicologySep 1, 2026PMID 42647088doi:10.1002/jbt.71086 PMC13512768Journal ArticlepubmedProvenance
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- Sep 13, 2026
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- ING-PUBMED-20260913-000001
Abstract
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Hepatocellular carcinoma (HCC) frequently demonstrates resistance to immunotherapeutic interventions, a phenomenon largely linked to mechanisms of immune escape. Among the modulators of the tumor microenvironment, SPARC (Secreted Protein Acidic and Rich in Cysteine), a matricellular glycoprotein,…
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- cancerMalignant Liver Neoplasmdictionary0.60
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