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Rapid normal fibroblast-tumor crosstalk promotes cancer-associated fibroblast-like activation and attenuates mitomycin C cytotoxicity in bladder cancer.

Jinhui Gao, Cindy Xinyu Ji, Ci Ren, John Hines, Eleanor Stride, Richard T Bryan, Jennifer L Rohn

Journal of cell communication and signalingSep 1, 2026PMID 42639377doi:10.1002/ccs3.70110 PMC13501395Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260908-000003
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Normal fibroblasts (NFs) are among the earliest stromal cells encountered by bladder cancer cells during invasion into the lamina propria, yet their contribution to tumor progression and intravesical chemotherapy response remains poorly defined. Here, we investigated whether NFs are passive stromal…

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