Publication
Repurposing minocycline to target FOXA1 and its mutants in prostate Cancer.
Ziyin Zhang, Jingwen Xu, Kai Zang, Yingshuang Zhang, Zhihao Liu, Yuxuan Song, Shaoya He, Yundong He
Cellular signallingDec 1, 2026PMID 42636948doi:10.1016/j.cellsig.2026.112843 Journal ArticlepubmedProvenance
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- PubMed
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- Sep 19, 2026
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- normalized (units and labels harmonized; values unchanged)
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- ING-PUBMED-20260919-000001
Abstract
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FOXA1 and the androgen receptor (AR) are essential for prostate cancer cell survival. Although current targeted therapies against AR are widely used, they frequently lead to drug resistance, partly due to alterations in FOXA1. Minocycline, a commonly prescribed antibiotic, has demonstrated…
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- cancerMalignant Prostate Neoplasmdictionary0.60
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