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Cancer-associated fibroblast-derived vascular endothelial growth factor a promotes gastric cancer organoid growth and chemotherapy resistance via paracrine signaling.

Hongmei Fan, Ling Wang, Chuanzhong Huang, Ruoxin Li, Linteng Zhang, Yunbin Ye, Lingyu Zhang

Cellular signallingDec 1, 2026PMID 42636947doi:10.1016/j.cellsig.2026.112837 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 19, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260919-000001
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BACKGROUND: Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment and can influence tumor progression and therapeutic response. However, whether functional heterogeneity of CAFs contributes to 5-fluorouracil (5-FU) resistance in gastric cancer remains…

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